Phenotype switch in patient with MLL rearrangement: a case presentation
Vol. 22 No. 3 (2018), Discussion
Vol. 22 No. 3 (2018)

Phenotype switch in patient with MLL rearrangement: a case presentation

Discussion
Published 2019-01-21
A Bertuzzi
Hospital de Agudos Carlos G. Durand, Buenos Aires, Argentina
J Barrera
Hospital de Agudos Carlos G. Durand, Buenos Aires, Argentina
MB Kolarovic
Hospital de Agudos Carlos G. Durand, Buenos Aires, Argentina
N Villaverde
Hospital de Agudos Carlos G. Durand, Buenos Aires, Argentina
ISSN 2250-8309 (versión en línea) - ISSN 0329-0379 (versión impresa)
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Keywords

acute lymphoblastic leukemia, acute myeloblastic leukemia, phenotype switch, lineage change, MLL

How to Cite

Bertuzzi, A., Barrera, J., Kolarovic, M., & Villaverde, N. (2019). Phenotype switch in patient with MLL rearrangement: a case presentation. Journal of Hematology, 22(3), 300–304. Retrieved from https://mail.revistahematologia.com.ar/index.php/Revista/article/view/44
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Abstract

Phenotype switch while treating acute leukemia is an uncommon event which has been described on pediatric patients and it is related to poor prognosis. Most reports have been acute lymphocytic leukemia (ALL) to acute myelogenous leukemia (AML) conversion, which are associated with the rearrangement on chromosome 11, involving the MLL gene. A clinical case of a 32-year-old man with diagnosis of pro B ALL is presented. A phenotype switch to AML was evidenced during treatment.

The presence of the MLL gene rearrangement was shown on both blast populations, in spite of their different immunophenotype, confirming the population shift.

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References

Stass S, Mirro J, Melvin S, Pui CH, Murphy SB, Williams D. Lineage Switch in Acute Leukemia. Blood. 1984; 61: 1138-1145.
2. Krawczuk-Rybak M, Zak J, Jaworowska B. A lineage switch from AML to ALL with persistent translocation t(4;11) in congenital leukemia. Med Pediatr Oncol. 2003 Jul;41(1):95-6.
3. Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, Bloomfield CD, Cazzola M, Vardiman JW. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016 May 19;127(20):2391-405.
4. Dorantes-Acosta E, Pelayo R. Lineage switching in acute leukemias: a consequence of stem cell plasticity? Bone Marrow Res. 2012;2012:406796.
5. Rossi JG, Bernasconi AR, Alonso CN, Rubio PL, Gallego MS, Carrara CA, Guitter MR, Eberle SE, Cocce M, Zubizarreta PA, Felice MS. Lineage switch in childhood acute leukemia: an unusual event with poor outcome. Am J Hematol. 2012 Sep;87(9):890-7.
6. Kawamoto H, Katsura Y. A new paradigm for hematopoietic cell lineages: revision of the classical concept of the myeloid-lymphoid dichotomy. Trends Immunol. 2009 May;30(5):193-200.
7. Park M, Koh KN, Kim BE, Im HJ, Jang S, Park CJ, Chi HS, Seo JJ. Lineage switch at relapse of childhood acute leukemia: a report of four cases. J Korean Med Sci. 2011 Jun;26(6):829-31.
8. Gagnon GA, Childs CC, LeMaistre A, Keating M, Cork A, Trujillo JM, Nellis K, Freireich E, Stass SA. Molecular heterogeneity in acute leukemia lineage switch. Blood. 1989 Nov 1;74(6):2088-95.

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