Keywords
HIV
lymphoproliferative disorders
plasmablastic lymphoma
Castleman's disease
How to Cite
Abstract
Lymphoproliferative lesions with plasmablastic/plasmacytoid appearance associated with KSHV/HHV8 in HIV patients most frequently found include multicentric Castleman disease (MCD), KSHV/ HHV8-associated diffuse large B-cell lymphoma (KSHV/HHV8+ DLBCL), primary effusion lymphoma, extracavitary primary effusion lymphoma, and more recently described, the KSHV inflammatory cytokine syndrome (KICS). These, more than separate entities, are considered a spectrum of clinical manifestations associated with KSHV/HHV8 infection. Patients with Kaposi's sarcoma are at higher risk of developing MCD and, in turn, those with
plasmablastic aggregates are more likely to progress to frank lymphoma associated with KSHV/HHV8. We present the clinical case of a 42-year-old male patient with HIV/AIDS and Kaposi's sarcoma who was later found to have histopathologically proven areas of MCD with KSHV/HHV8+ DLBCL. Additionally, a literature review of the differential diagnosis of this spectrum of entities is provided.
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